Effect of Myrtus communis on Healing of the Experimental Skin Wounds on Rats and its Comparison with Zinc Oxide

Wound healing in some chronic diseases and disorders has become one of the challenges of medical science and for this reason using the new compounds to accelerate wound healing is produced will be welcomed. In the meantime, the Myrtus herb has antibacterial and anti-inflammatory, antiseptic and anti- congestive effects. Based on this information, the purpose of this study was to studying the effect of this plant extract on process of wound healing. In this study, after induction of anesthesia in 48 male rats weighing 200 to 250 g and approximately one and a half months of age, using a biopsy punch with a diameter of 23 mm circular wound was created on the dorsal skin region of each of them. Then the rats were divided into four groups, each groups continued healing process with 5 and 10% extract of Myrtus herb mg/cm 2, 35 dose once- daily, eucerin (drugs) and control (distilled water). Test duration was 28 days, wound diameter measurement using digital image analysis and Histopathological study on days 0, 3, 7, 14, 21 and 28 with biopsy two rats from each group were took. These rats were removed from the investigation process after obtaining biopsies. Obtained Results were analyzed with ANOVA and TUKEY test (p<0.05). The results revealed that treatment with low-dose group of Myrtus herb extract (5%) most shrinkage of wound area and also from the perspective of Histopathological change. in the second and third week, tissue had better organization than most other groups (p<0.05), but the group treated with high doses of Myrtus herb extract (10%) had less wound shrinkage and organization. "-pinene (18%), limonene (20%), 1.8 cineole (5%), linalool (16%), linalyl acetate (8.16%), myrtenyl acetate (9%), geranyl acetate (3%), "-humulene (2%), "-terpineol (1.5%), trans-caryophyllene (1%), methyl eugenol (1%), trans-$-ocimene (0.9%), "-terpinolene (0.9%), along with minor quantities of eugenol (0.4%), neryl acetate (0.4%),