The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution

Modi Safra,Aldema Sas-Chen,Ronit Nir,Roni Winkler,Aharon Nachshon,Dan Bar-Yaacov,Matthias Erlacher,Walter Rossmanith,Noam Stern-Ginossar,Schraga Schwartz

The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution

2017

Modi Safra
Aldema Sas-Chen
Ronit Nir
Roni Winkler
Aharon Nachshon
Dan Bar-Yaacov
Matthias Erlacher
Walter Rossmanith
Noam Stern-Ginossar
Schraga Schwartz

Transcriptome-wide mapping of N1-methyladenosine (m1A) at single-nucleotide resolution reveals m1A to be scarce in cytoplasmic mRNA, to inhibit translation, and to be highly dynamic at a single site in a mitochondrial mRNA.

Keywords:

Cytoplasm
Cytosol
Cell biology
Messenger RNA
Biology
Sequence motif
Structural motif
Transfer RNA
RNA
Methylation
TRNA Methyltransferases
Protein biosynthesis
Regulation of gene expression

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