Synchronization and Desynchronization of the "Hypertensive" Heart

As we have previously shown [3,4], there is a reliable strong positive correlation between the parameters characterizing the real and potentially attainable contractility of the ventricles in the intact heart, whereas under conditions of the development of a pathological process these relationships weaken, this being indicative of a disturbed activity of the heart as a dynamically synchronized system. The disturbed synchronicity of the activity of different portions or even regions of the heart has been noted in a number of pathological states [1,5,7], this desynchronization probably leading to disturbances of the heart rhythm as well as to a reduction of the reserve of myocardial contractihty. Since this problem has received practically no attention in the current literature on the pathogenesis of arterial hypertension and its t reatment [6,8,9], in the present study we analyzed the level of heart synchronicity at different stages of development of hypertension.