Successful ventricular application of the miniaturized controlled-delivery. Accurel technique for sustained enhancement of cerebrospinal fluid peptide levels in the rat

Abstract A recently developed small controlled-delivery peptide device has now been further miniaturized (3.5 mm 3 rod) and its action has been tested in vitro and in vivo using vasopressin (VP) as experimental substance. In vitro immersion showed a constant and lasting release of VP for weeks, as had been described for larger devices. By introducing the mini-device into the lateral ventricle of rat brain and by sampling CSF via a permanent cannula in the cisterna magna, a steadily enhanced level of VP could be attained for CSF. These increased levels persisted for one week, but most likely continue for longer periods.