Peripheral Reticular Pigmentary Change Is Associated with Complement Factor H Polymorphism (Y402H) in Age-Related Macular Degeneration

Objective To examine phenotypes of age-related macular degeneration (AMD) patients with the complement factor H (CFH) variant (Y402H, C allele at rs1061170). Design Clinic-based case series study. Participants The data set contained a total of 956 unrelated cases of AMD. Methods Age-related macular degeneration phenotypes of 796 carriers of the CFH Y402H variant were compared with the AMD phenotypes of 160 noncarriers. Main Outcome Measures Presence or absence of 34 phenotypic features. Results Of the 34 features analyzed, only peripheral reticular pigmentary change (PRPC) was associated with this CFH variant ( P = 0.0006). The proportion of AMD cases with PRPC correlated with the number of CFH risk C alleles in a dose–response fashion. Conclusions The CFH Y402H polymorphism is associated with PRPC, suggesting that AMD changes are not limited to the macula. Current AMD grading methods assess only the macula and should consider incorporating peripheral retinal changes. Phenotypes that suggest a high-risk genotype may prove valuable for diagnostic, therapeutic, and research purposes.