COVID-19 in an Immunocompromised Host: Persistent Shedding of Viable SARS-CoV-2 and Emergence of Multiple Mutations, a Case Report.

We report a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukemia presenting with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), who remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.