Trospium chloride synthesis process

The present invention provides a trospium chloride synthesis process, comprising the following: ① From Preparation benzilic chloride; ② preparing tropenol norepinephrine; ③ Preparation chloride (3alpha-norepinephrine tropenol) -8- spiro-1-pyrrolidinyl salts; ④ preparation trospium chloride: take benzilic acetyl chloride chloride (3alpha-norepinephrine tropenol) -8-1-pyrrolidinyl spiro ammonium salt condensation trospium . Advantage of the present invention are: less steps atom economy strong, high yield, low production cost, while the method using Pd / C catalytic hydrogenation of methyl off, the catalyst can be applied several times, with less reduced Pollution. After the reaction process without complicated processes.