Usnic Acid Conjugates with Monoterpenoids as Potent Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

Olga A. Luzina,Alexander Filimonov,A. L. Zakharenko,Arina A. Chepanova,Olga D. Zakharova,Ekaterina S. Ilina,N. S. Dyrkheeva,Galina N. Likhatskaya,Nariman F. Salakhutdinov,Olga I Lavrik

Usnic Acid Conjugates with Monoterpenoids as Potent Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

2020

Olga A. Luzina
Alexander Filimonov
A. L. Zakharenko
Arina A. Chepanova
Olga D. Zakharova
Ekaterina S. Ilina
N. S. Dyrkheeva
Galina N. Likhatskaya
Nariman F. Salakhutdinov
Olga I Lavrik

Hybrid molecules created from different pharmacophores of natural and synthetic equivalents are successfully used in pharmaceutical practice. One promising target for anticancer therapy is tyrosyl-...

Keywords:

Tyrosyl-DNA Phosphodiesterase 1
Biochemistry
Conjugate
Usnic acid
Biology
Pharmacophore
Stereochemistry

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