A Preliminary Study of Anti-1-Amino-3-18F-Fluorocyclobutyl-1-Carboxylic Acid for the Detection of Prostate Cancer

We evaluated the feasibility of anti-1-amino-3-18F-fluorocyclobutyl1-carboxylic acid (anti- 18 F-FACBC) in diagnosing prostate cancer (PCa), using a rat orthotopic prostate cancer transplantation (OPCT) model. Furthermore, using in vivo experiments, we examinedthepotentialofanti-18F-FACBCfordifferentiatingbetweenPCa and inflammation and between PCa and benign prostatic hyperplasia(BPH). Methods:TheOPCTmodelwasdevelopedbytransplantingDU145,ahumanPCacellline,intotheventralprostateofathymic F344 rats. To develop a dual PCa and inflammation (DPCI) model, MAT-Ly-Lu-B2—a rat PCa cell line—was transplanted subcutaneously into male Copenhagen rats. Streptozotocin was injected into the hind footpad of these rats for inducing popliteal lymphadenitis. For inducing the BPH, normal F344 rats were castrated and injected