Ferulic Acid and Angelica archangelica Extract in Dementia: Effects on Cognitive Functions and Behavioral and Psychological Symptoms of Dementia

Symptoms of dementia are classified as “cognitive disturbance” and “behavioral and psychological symptoms of dementia.” Understanding how to inhibit the progression of cognitive disturbance and control the behavioral and psychological symptoms of dementia are the most important problems associated with this disease. Ferulic acid is a nutrient that exists in many kinds of grains, whereas Angelica archangelica is a biennial plant from the umbelliferous family Apiaceae. Our studies have shown that treatment with ferulic acid and A. archangelica extract suppressed the development of mild cognitive impairment in dementia and also improved the behavioral and psychological symptoms of frontotemporal lobar degeneration or dementia with Lewy bodies. There were no adverse effects or significant changes in the physical findings or laboratory data during treatment. Our findings suggest that ferulic acid and A. archangelica extract is extremely safe and represents a useful therapeutic tool for patients with mild cognitive impairment and dementia.