The Ugi Reaction of Cyanoacetic Acid as a Route to Tetramic Acid Derivatives

Nancy V. Alvarez-Rodríguez,Aurélie Dos Santos,Laurent El Kaim,Rocío Gámez-Montaño

The Ugi Reaction of Cyanoacetic Acid as a Route to Tetramic Acid Derivatives

2015

Nancy V. Alvarez-Rodríguez
Aurélie Dos Santos
Laurent El Kaim
Rocío Gámez-Montaño

Ugi adducts of cyanoacetic acid and aromatic aldehydes are readily cyclized under basic conditions leading to one-pot formation of aminopyrrolinone derivatives.

Keywords:

Adduct
Tetramic acid
Photochemistry
Cyanoacetic acid
Organic chemistry
Ugi reaction
Isocyanide
Chemistry

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