The effects of vitamin E on the skin lipid peroxidation and the clinical improvement in vitiligo patients treated with PUVA

Vitiligo affects men and women equally and can occur at any age. The etiology of the disease is still unknown [1]. Besides the most popular autoimmune theory, several groups have recently shown the involvement of oxidative stress in the pathophysiology of this disease [2, 3]. The mechanism by which oral psoralens and UV-A radiation (PUVA) stimulate melanocyte proliferation in vitiligo and other hipopigmentary diseases is not known [4]. [...]