New series of aryloxypropanolamines with both human β3-adrenoceptor agonistic activity and free radical scavenging properties

Abstract A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the β 3 -adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-, di- tert- butylphenolyl- or methoxyindolyl-type. Some of the products possessed both the expected activities.