Суммарный сердечно-сосудистый риск у больных гипертонической болезнью: возможности ингибиторов ангиотензинпревращающего фермента

Aim. To assess cumulative cardio-vascular (CV) risk and elasticity of big-to-middle size arteries in hypertensive patients depending on age, sex and enalapril (Enap, Dr. Reddy's) effects on these features. Material and methods. 143 patients with arterial hypertension of 1-2 stages were split in 3 groups: 1st patients younger than 55 y. o. (17men, 27 women before menopause); 2nd patients aged 55-65 y. o. (16 men, 38 women); 3rd elder than 65 y. o. (11 men, 34 women). Fatal CV risk according to SCORE scale and cumulative risk of acute coronary disease (CAD) events according to PRCAM-programwas assessed before and after 4weeks of enalapril therapy (5-30mg/d). Besides the speed of pulsewave spread (SPWS) was determined by method of volume sphygmography. Results. Normal SPWS in elastic arterieswas observed in women under 55 y.o. SPWS disturbances were detected in elderly patients. Lower blood pressure (BP) levels and better plasma lipid profile was found in women of young and middle age in comparison with these in men of the same age. More than 80 % of hypertensive patients have high CV risk, especially in elderly ones. Enam improved SPWS in elastic arteries, reduced BP and cumulative CV risk. Conclusion. There are gender and age differences between BP levels, SPWS indices, plasma lipid profiles and cumulative CV risks in hypertensive patients. Enalapril improves these characteristics. Rational Pharmacother. Card. 2007; 5: 9-14