Therapeutic strategy for gastric cancer with positive peritoneal lavage cytology without peritoneal dissemination

: We analyzed the prognosis of patients with positive lavage cytology, excluding other unresectable factors.From 2002 to 2008, 76 advanced gastric cancer patients positive for malignant cells(CY1)were investigated for our study.There were 60 patients undergoing gastric cancer surgery.Sixteen patients were treated by chemotherapy only. The MST of the chemotherapy group was 427 days, and that of the gastrectomy group was 442 days, although this was not statistically significant.The multimodality therapy group undergoing gastrectomy and chemotherapy consisted of 42 patients.The MST of this group was 647 days.In the multimodality therapy group, there were 28 patients undergoing chemotherapy using S-1.The MST of this group was relatively better(1, 249 days).CY1 appeared to be a worse prognostic factor, but P0CY1 survival was better than in P1. As a therapeutic strategy for gastric cancer with positive peritoneal lavage cytology, multimodality therapy with gastrectomy and chemotherapy using S-1 may be effective.