Dopamine and myopia in retinopathy of prematurity

Retinopathy of prematurity (ROP) is a kind of abnormal neovascularization and fibrous tissue proliferation retinopathy in premature and low birth weight infants. It is regarded as one of the important diseases causing visual impairment in children, which can lead to permanent visual loss. A large number of domestic and foreign study found that ROP affected retinal development and function, mainly affected the light-sensitive cells, and clinical study found that the retinal dysfunction even early controlled, usually following the ametropia, especially myopia. Recent studies have found that oxygen induced retinopathy (OIR) retinal dysfunction may be related to the release of dopamine (DA) and the changes in the activity of DA. Studies found that ROP early myopia and the high incidence of myopia in children with ROP were closely related to the effect of ROP on the secretion and release of dopamine in the retina. Therefore, discussing the role of DA in ROP myopia will provide a new way of thinking for the prevention and treatment of myopia in children with ROP. (Int Rev Ophthalmol, 2016, 40: 258-262) Key words: retinopathy of prematurity; dopamine; myopia; photoreceptor cells; electroretinogram