Pharmacokinetics of fangchinoline and tetrandrine in rats

Objective:To investigate the pharmacokinetics profile of fangchinoline and tetrandrine in rats after administration of single compound and mixture with other intergradient in traditional prescription.Method: A method for determination of fangchinoline and tetrandrine in rat plasma by using HPLC-MS has been developed and validated.The pharmacokinetics of two compounds and two compounds in the effective component group(ECG) of Xiaoxuming decoction were compared.Result: Compared with the single dose of compound experiment results,the tmax of fangchinoline and tetrandrine were longer than those in the single dose of ECG experiment.At the meanwhile the rest parameter showed no significant difference.Conclusion: Other components in the ECG of Xiaoxuming decoction delayed the absorption rate of fangchinoline and tetrandrine,the bioavailability of two compounds were the same as that of the single dose of compound experiment.