Predictors of Airway Intervention in Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema.

ObjectivesIdentify factors associated with angiotensin-converting enzyme inhibitor–induced angioedema (AIIA), including (1) time of presentation, (2) clinical symptoms, and (3) anatomical regions in the head and neck, that may indicate need for airway intervention.Study DesignCase series with chart review.SettingThree university tertiary care hospitals.Subjects and MethodsMedical records of adult patients presenting to the emergency department (ED) diagnosed with AIIA within a 3-year period were reviewed. Time at presentation, presenting symptoms, physical examination findings, treatment, length of hospitalization, and outcomes were examined. Univariate analysis was performed.Results311 patients were diagnosed with AIIA and evaluated with flexible laryngoscopy by an otolaryngologist. Patients requiring airway intervention most often presented within 4 hours of onset. Dysphagia, dysphonia, drooling, respiratory distress, and globus sensation were associated with airway intervention (χ2 range, 9.1-47.1). Pa...