Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport

Daqing Jin,Terri T. Ni,Jianjian Sun,Haiyan Wan,Jeffrey D. Amack,Guangju Yu,Jonathan T. Fleming,Chin Chiang,Wenyan Li,Anna Papierniak,Satish B. Cheepala,Gwenaëlle Conseil,Susan P. C. Cole,Bin Zhou,Iain A. Drummond,John D. Schuetz,Jarema Malicki,Tao P. Zhong

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport

2014

Daqing Jin
Terri T. Ni
Jianjian Sun
Haiyan Wan
Jeffrey D. Amack
Guangju Yu
Jonathan T. Fleming
Chin Chiang
Wenyan Li
Anna Papierniak
Satish B. Cheepala
Gwenaëlle Conseil
Susan P. C. Cole
Bin Zhou
Iain A. Drummond
John D. Schuetz
Jarema Malicki
Tao P. Zhong

Zhong and colleagues report that zebrafish leakytail (Lkt) promotes ciliogenesis by exporting prostaglandin E2 to upregulate cAMP synthesis. A human orthologue of Lkt, ABCC4, is also important for ciliogenesis in human retinal pigment epithelial cells.

Keywords:

Prostaglandin E2
Prostaglandin
Cell biology
Intraflagellar transport
Transport protein
Ciliogenesis
Zebrafish
Cilium
HEK 293 cells
Biology

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