RNase L: Its Biological Roles and Regulation
2006
2'-5'oligoadenylate-dependent ribonuclease L (RNase L) is one of the key enzymes involved in the function of interferons (IFNs), a family of cytokines participating in innate immunity against viruses and other microbial pathogens. Upon binding with its activator, 5'-phosphorylated, 2'-5' linked oligoadenylates (2-5A), RNase L degrades single-stranded viral and cellular RNAs and thus plays an important role in the antiviral and antiproliferative functions of IFNs. In recent years, evidence has revealed that RNase L displays a broad range of biological roles which are summarized in this review. iubmb Life, 58: 508-514, 2006
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
40
References
75
Citations
NaN
KQI