Cytisine-like alkaloids from Ormosia hosiei Hemsl. & E.H. Wilson
2014
Abstract Four alkaloids named hosieines A–D were isolated from the root and stem of Ormosia hosiei . Their flat structures were established by mass spectrometry and by a combination of NMR experiments. These molecules probably share a common biosynthetic origin with the lupin alkaloids but they differ in the formation of the last ring, being here part of a rare 2-azabicyclo[3.2.1]octane system. Their absolute configuration was determined by X-ray crystallography using CuKα radiation. As has been described for cytisine, they display a remarkable affinity towards neuronal nicotinic acetylcholine α 4 β 2 receptor.
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