Influence of neoadjuvant treatment of rectal carcinoma on operability and incidence of distant metastases.
2013
In the Czech Republic, rectal carcinoma does not only represent
a medical problem, but also a socio-economic one. At our
department, we treated totally 266 patients with rectal
carcinoma in the years 1998 through 2006. Among our patients,
neoadjuvant treatment led to a reduction in size of the tumour
in 37.6 %, in 50.8 % the size did not change. In T3 tumours,
the reduction in size was observed in 36.7 % of the patients
and did not change in 56 %; in T4 tumours, the reduction in
size was observed in 60% of the patients. In 88 % of the
patients who underwent the operation, no residual tumour was
found, in 9 % of patients, a residual tumour was detected. In
19 % of the patients, a local recurrence of the tumour was
detected. A statistically significant relationship was proved
between the appearance of the metastatic disease and the
presence of angioinvasion and the size of the primary tumour
according to the Duke’s classification.
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