High-Risk Clonal Hematopoiesis as the Origin of AITL and NPM1-Mutated AML

Two Cancers in CHIP A patient with clonal hematopoiesis of indeterminate potential (CHIP) received the diagnosis of lymphoma with activation of RHOA. Approximately 1 year later, NPM1-mutated acute leukemia developed with the same CHIP mutations but without mutated RHOA.