A. Assessment of Antianginal Drugs Through Studies of the Peripheral Circulation

In this chapter, consid'eration of the test methods that can be used to study the peripheral circulation will be confined mainly to those which can be applied to human limbs. The peripheral circulation could be defined in a much wider sense than this, to include the circulation through all the peripheral organ systems, but the chapter will be restricted to tests that can be used to assess skin and muscle blood flow. The human limbs are extremely well adapted for experimental vascu­ lar studies and have played an important part in the acquisition of clinical phar­ macological knowledge. While the symptoms of angina pectoris and their relief by antianginal drugs