Expression of serum-and glucocorticoid-induced kinase 1 in renal glomeruli of patients with obstructive nephropathy and its response to Curcumin

Objective: To investigate the dynamic expression of serum-and glucocorticoid-induced kinase 1(SGK1) in the renal glomeruli of nephropathy patients with unilateral urethral obstruction(UUO) and its response to Curcumin.Methods: Fifty-four Sprague-Dawley rats were randomly divided into a sham operation,a UUO model and a Curcumin treatment group of 18 each.Six rats of each group were killed respectively at 3,7 and 14 days after surgery,the levels of blood urea nitrogen(BUN) and serum creatinine(SCr) observed,and the expression of the renal glomerular SGK1 protein detected by immunohistochemistry. Results: The renal glomerular SGK1 was up-regulated in the UUO model group from the 3rd to the 14th day.While in the Curcumin treatment group,a significant decrease was observed in the expression of renal glomerular SGK1,but with no obvious change in the level of BUN and SCr.Conclusion: The expression of renal glomerular SGK1 remains high with the progression of UUO,which suggests that SGK1 may play an important role in the development of obstructive nephropathy.Curcumin could prevent renal glomerular fibrosis by inhibiting the expression of SGK1.