And dry granules milled procedures

A granulate comprising a pharmaceutically active ingredient and a medium granulated excipient obtienepor of: drying a wet granulate having an initial moisture content to a relative moisture content default is between about 30% and about 85% less dedicho initial moisture content to form a partially wet and dried granulate, comprising elgranulado wet the pharmaceutically active ingredient and the excipient; milling said partially dried granulate to obtain a milled granulate quepresenta partially dried and a size distribution of predetermined particle; and drying said granulate and milled partially dried granulate to produce said wherein said pharmaceutically active ingredient is oxycodone.