[Sero-epidemiology of six viruses natural infection in Tupaia belangeri chinensis].
2011
Tupaia ( Tupaia belangeri chinensis , tree shrew) as a new experiment
animal in medicine are non-rodent, small animals and close to primates
in evolution. Experimental animals infected with viruses will affect
the animal’s health, interference experiment, and even endanger
the operator’s safety. Therefore, the viral infection in
experimental animals has long been considered an important part of
quality control. Lack of clearer viral natural infection information on
the T. belangeris limits its use. Six viruses infection in 272 wild
capture and artificial breeding Tupaia were investigated in this study.
All serum samples were detected for the hepatitis B virus surface
antigen, the total antibodies of HCV, hepatitis E virus (HEV),
adenovirus (ADV), herpes simplex virus type 1 (HSV-1) and herpes
simplex virus type 2 (HSV-2) by ELISA. The results showed that anti-HCV
antibody and anti-HEV, ADV, HSV-1 IgG antibodies were negative, only
one sample was positive of anti-HSV-2 IgG.. Three samples were positive
in the primary ELISA detection of HBV surface antigen, but two pairs of
semi-quantitative detection of hepatitis B and further recognized as
negative. The results implied that antigen or antibody-positive results
appeared in the hepatitis serological test is not accurate enough and
confirmation by other virological indicators is necessary. Tupaia
breeding herd should be screened for HSV-2 in order to prevent and
control the virus infection.
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