[Side effects of extra-amniotic PGF2 alpha in the induction of labor in retained abortion and in the intrauterine death of the fetus].

: The tolerance of (PGF2alpha) prostaglandin F2alpha used for the induction of abortive labor has been studied in a group of 40 patients. The drug was administered in the extraamniotic intracavitary space. Apart from minor gastrointestinal and peripheral vascular side effects which were well-tolerated, a severe bronchospastic reaction with arterial hypotension and bradycardia was observed in a case of retained abortion at the 22nd week. This was treated with PGF2alpha delivered extraamniotically according to Csapo's double impact technique. In this patient, certain signs such a bradycardia cleared up just a few minutes after resuscitation, while the bronchospasm and peripheral cyanosis only ceased after 2 hours. It is considered that this reaction was determined by the rapid absorption of a large quantity of drug in the general circulation or by a condition of hypersensitivity to PGF2alpha. (author's)