Letter by Houston et al Regarding Article, “Localized Optogenetic Targeting of Rotors in Atrial Cardiomyocyte Monolayers”

We read with great interest the article by Feola et al1 on investigating the mechanisms of rotor-guided ablation through optogenetic stimulation in monolayers of neonatal rat atrial cardiomyocytes. The authors optically map single stable rotors which could be reliably initiated in their homogeneous monolayers and report on the success rate of different light ablation approaches to terminate the rotors by localized conduction block. We previously studied similar rotor activity using high spatiotemporal resolution optical mapping in monolayers …