Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production

Sonja I. Gringhuis,Tanja M. Kaptein,Brigitte A. Wevers,Michiel van der Vlist,Elsenoor J. Klaver,Irma van Die,Lianne E.M. Vriend,Marein A. W. P. de Jong,Teunis B. H. Geijtenbeek

Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production

2014

Sonja I. Gringhuis
Tanja M. Kaptein
Brigitte A. Wevers
Michiel van der Vlist
Elsenoor J. Klaver
Irma van Die
Lianne E.M. Vriend
Marein A. W. P. de Jong
Teunis B. H. Geijtenbeek

Dendritic cells (DCs) initiate distinct arms of immunity in response to different classes of pathogens. Here Gringhuis et al. show that DCs produce IL-27 upon sensing fucose-containing pathogen ligands via DC-SIGN, promoting follicular T helper cell differentiation and antibody production.

Keywords:

Immunity
Antibody
Follicular dendritic cells
DC-SIGN
Pathogen
T helper cell
Fucose
Molecular biology
T-helper cell differentiation
Biology
Follicular phase

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