Axial ligand substitution in diastereoisomeric trans-[Co(Me8 14ane)Cl2]+ complexes and their anti-fungal activities

Three isomeric Me8 14anes, LA, LB and LC, on aeration with cobalt(II) acetate tetrahydrate and subsequent treatment with concentrated HCl and HClO4, give green trans-[CoLCl2]ClO4 diastereoisomers. Whereas the macrocyclic ligands LA and LB yield two N-chiral diastereoisomers, LC gives one isomer. The complexes undergo axial ligand substitution with small ligands such as , SCN−, OH− and H2O to produce corresponding trans products. Anti-fungal activities of the complexes against a range of phytopathogenic fungi have been investigated.