Isolated high-molecular-weight kininogen deficiency: a novel frameshift mutation in exon 10

To the editor: In the June 1, 2003, issue of Blood , Krijanovski et al presented a single–base pair deletion in cDNA position 1492 of exon 10 in a family with isolated high-molecular-weight kininogen (HK) deficiency.[1][1] This deletion affected amino acid 498 of the mature protein and resulted