The biorhythmology of primary and superinvasive opisthorchiasis. Seasonal changes in the circadian dynamics of the peripheral blood composition in golden hamsters

: 540 golden hamsters were selected into 3 groups: 1--free from invasion, 2--once infected, 3--repeatedly infected with Opisthorchis felineus. Diurnal activity of peripheral blood composition was investigated in spring, autumn and winter at 3, 7, 11 a.m. and 3, 7, 11 p.m. The dependence of biorhythmical organisation of peripheral blood cell composition upon seasons and the opisthorchis invasion frequency was recovered. The eosinophilia is the marker reaction of opisthorchiasis acute phase and it depend upon the invasion frequency. Seasons and invasion frequency affect on all diurnal rhythm components (mezor, acrophase, amplitude) with most largest drift in spring.