Cystathionine- γ-lyase promotes process of breast cancer in association with STAT3 signaling pathway

// Jing You 1 , Xiaoyan Shi 1 , Huimin Liang 2 , Juan Ye 1 , Lupeng Wang 1 , Huanxiao Han 1 ,Hongyu Fang 1 , Wenyi Kang 1 and Tianxiao Wang 1 1 College of Pharmacy, Henan University, Kaifeng 475004, Henan Province, China 2 Huaihe Hospital, Henan University, Kaifeng 475000, Henan Province, China Correspondence to: Tianxiao Wang, email: wtx1975@126.com Keywords: cystathionine-γ-lyase, H2S, transcription factor STAT3, breast cancer, growth Received: May 25, 2017      Accepted: July 25, 2017      Published: August 07, 2017 ABSTRACT Here we provide evidences to link cystathionine-γ-lyase (CSE) to the development of breast cancer. CSE expression is up-regulated in both breast cancers and breast cancer cell lines and results in proliferation and migration of breast cancer cells. CSE Function in breast cancer depends on the STAT3 signaling pathway, a regulator of critical cell functions including cell growth in a wide variety of human cancer cells via activating the expression of relative genes. STAT3 positively relates to CSE expression. It activates the CSE promoter via a direct binding to the promoter. Moreover, CSE could reversely regulate STAT3 expression and consequently enhance the effect of STAT3 on CSE. Taken together, these data demonstrate for the first time the roles of CSE in breast cancer leading to breast cancer development in association with STAT3 signaling pathway.