Optimal Conditions for Tumor Chemotherapy Chosen on the Basis of Changes in the Lipid Antioxidant Activity

Changes in antioxidation activity of lipids (AOA) from tumor and tissues of tumor host have been studied in the course of tumor growth, by action of various chemotherapeutic drugs on intact animals and tumor hosts. It was found that development of a number of inoculated tumors ran parallel with increasing AOA of tumor host organs, and such AOA changes were important and characteristic of tumor growth. Different antineoplastic drugs suppressed the tumor and normal cell division more strongly with decreasing AOA value. Compounds increasing AOA accelerated tumor growth. Study of AOA changes in course of tumor growth gave the possibility of following changes in the sensitivity of tumors and organs of tumorhosts relative to the action of antineoplastic drugs, and to choose the optimal conditions of rational therapy. Experimental data permit the conclusion that the use of drugs of the same class for action on a tumor at any stage of its growth is absolutely ineffective and the use of intermittent administration of alkylating agents and antioxidants might be promising.