Экспериментальное обоснование возможности применения ресвератрола для фармакологического прекондиционирования в хирургии

The possibility of using Resveratrol for pharmacological preconditioning in surgery is studied. The experiment was carried out on Wistar rats. The influence of Resveratrol on the survival of isolated skin pedicle flap and the microvasculature condition in the ischemic skeletal muscle was determined in comparison with the effect of distant ischemic preconditioning. Ischemia was modeled on leg muscles of rats. The microvasculature condition was assessed by laser Doppler flowmetry and histological examination. It was revealed that Resveratrol improves the survival of isolated skin pedicle flap and stimulates angiogenesis in the ischemic leg muscles of rats. The obtained results allow the possibility of further experimental studies of Resveratrol for pharmacological preconditioning in surgery.