Effect of malate and NAD on local myocardial contraction during acute coronary occlusion

: In acute experiments on cats the effects of malate (100 mg/kg), NAD (0.2 mg/kg) and their combination on regional myocardial contractility were studied during acute coronary artery occlusion. All the drugs increased significantly myocardial contractility in border and intact zones. However, the response of the central ischemic zone to drug effects was insignificant.