Low molecular weight agonist antibody

The present invention is to signal transduction into cells by crosslinking a cell surface molecule may act as an agonist, to the modified antibody comprising an H chain V region of a monoclonal antibody more than one and L chain V region of two or more. The modified antibody can be used as agonists of signaling, useful cancer, inflammation, as a hormone abnormality, prevention of various diseases such as blood disorders and / or therapeutic agent or the like.