trans-5-prostaglandin E2 stimulates plasminogen activation by tissue-type plasminogen activator.

Abstract The effect of trans -5-prostaglandin E 2 ( trans -PGE 2 ) on fibrinolysis was examined in vitro using synthetic chromogenic substrate S-2251. trans -PGE 2 was found to enhance plasminogen (PLG) activation mediated by tissue-type plasminogen activator (tPA). The enhancing effect was dependent on the concentration of trans -PGE 2 . cis -PGE 2 and the other PGs (PGE 1 and PGI 2 ) did not show such an effect as trans -PGE 2 , despite to the fact that their structures are similar to that of trans -PGE 2 . trans -Configuration around the double bond at the 5-position seems to be important in the enhancement of the fibrinolytic activity.