4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.

Since biochemical studies indicated early on that certain 4-amino [1,2,4] triazolo [4,3-a]-quinoxalines also displayed affinity for adenosine receptors and inhibitory effects on phosphodiesterase, we explored the structure-activity relationship (SAR) of these end-points as well. Furthermore, since the psychomotor stimulant caffeine has biochemical properties similar to compounds in this series and is also active in the swim test, we carried out behavioral tests to evaluate the contribution of stimulant properties to activity in the swim test