Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice

Rinku Dutta,Virender Kumar,Yang Peng,Ruby E. Evande,Jean L. Grem,Ram I. Mahato

Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice

2017

Rinku Dutta
Virender Kumar
Yang Peng
Ruby E. Evande
Jean L. Grem
Ram I. Mahato

Purposes To determine the pharmacokinetic parameters and biodistribution of GDC-0449 loaded polymeric micelles after systemic administration into common bile duct ligation (CBDL) induced liver fibrotic mice.

Keywords:

Common bile duct
Biochemistry
Systemic administration
Chemistry
Pharmacokinetics
Biodistribution
Micelle
polymeric micelles
common bile duct ligation
pharmacology toxicology
Pathology
liver fibrosis
Pharmacology

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