Pregnancy following combination chemotherapy for a mixed germ cell tumor of the ovary

Abstract The introduction of combination chemotherapy for management of patients with germ cell tumors of the ovary has dramatically improved prognosis. Until recently prognosis for patients with Stage I mixed germ cell tumors had been dependent upon the size of the tumor and its germ cell constituents. This report will present a patient with a ruptured mixed germ cell tumor composed predominantly of endodermal sinus tumor elements with foci of dysgerminoma, who was then treated postoperatively with vincristine, actinomycin D, and cyclophosphamide, and subsequently has had two normal-term pregnancies following a negative second-look operation and is alive and free of disease 5 years following the original diagnosis.