Synthesis of the enantiomer of nelarabine

Karim Herbal,John Kitteringham,Martyn Voyle,Andrew Jonathan Whitehead

Synthesis of the enantiomer of nelarabine

2005

Karim Herbal
John Kitteringham
Martyn Voyle
Andrew Jonathan Whitehead

Abstract A synthesis of the enantiomer of nelarabine is described. Subtle changes in the protecting group strategy allow for an efficient inversion of the C-2′ stereocentre.

Keywords:

Organic chemistry
Nucleic acid
Enantiomer
Stereochemistry
Nelarabine
Protecting group
Chemistry

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