474 THE PREDICTION OF CHRONIC RENAL DYSFUNCTION FOLLOWING LIVER TRANSPLANTATION: A TIME-DEPENDENT ANALYSIS

10% of patients were non adherent to therapy, to outpatient visit and to requested blood tests, respectively. Non adherent vs. good adherent patients had better MELD at LT (p = 0.04), were drinking alcohol (p = 0.001) and reported >3 side effects of IS (p = 0.02). At 12 months after LT 60%, 50% and 50% of patients were non adherent to therapy, to outpatient visit and to requested blood tests, respectively, significantly worse compared to 6 months evatuation. Non adherent vs. good adherent patients, were younger (p = 0.05), had better MELD at LT (p = 0.04), were drinking alcohol (p = 0.001) and reported >3 side effects of IS (p = 0.02). 50% of patients with poor adherence after LT, had poor adherence before LT. Conclusions: Adherence to medical regimen is poor in cirrhotic patients being the risk factors to be divorced and having good liver function. It seems that adherence improves in the short-term, but deteriorates again in the longer time after LT, when being relatively stable at LT and experiencing side effects due to IS are associated with poor adherence. Educational programs for such patients are badly needed.