2-Pyridinoformamide-derived thiosemicarbazones and their iron(III) complexes : Potential antineoplastic activity

Abstract The iron(III) complexes [Fe(2Am4DH) 2 ]Cl ( 1 ), [Fe(2Am4Me) 2 ]Cl ( 2 ) and [Fe(2Am4Et) 2 ]Cl ( 3 ) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N (4)-methyl (H2Am4Me) and N (4)-ethyl (H2Am4Et) derivatives were obtained and characterized by means microanalyses, infrared and EPR spectra. The electrochemical behavior of the complexes was investigated. The thiosemicarbazones and complexes ( 1 ) and ( 2 ) presented toxicity against Artemia salina at low concentrations. Since this bioassay has a good correlation with cytotoxic activity in human solid tumors, the studied compounds present potential pharmacological applications.