Insights in the organization of DNA-surfactant monolayers using cryo-electron tomography

We demonstrate that for the present system the general view on DNA−cationic surfactant Langmuir monolayers, in which DNA is bound directly underneath a closed monolayer surface, is only applicable when DNA is injected underneath a preformed monolayer. Moreover, cryo-electron tomography showed that the DNA strands do not bind completely to the monolayer surface in an orderly fashion, but partially extend down into the subphase.