Serum levels of PCDDS and PCDFS among workers exposed to 2,3,7,8-TCDD contaminated chemicals

Abstract The National Institute for Occupational Safety and Health (NIOSH) collected serum from workers exposed to chemicals contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and from unexposed referents. A subset of serum samples were analyzed for polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs). In addition to a marked difference in serum levels between workers and referents for 2,3,7,8-TCDD, there was a small but significant difference for 2,3,7,8-PnCDF and 1,2,3,4,7,8-HxCDF. Funding was received for this study from the Agency for Toxic Substances and Disease Registry.