Study of complexation of dopamine analogues with bioactive metals by cyclic voltammetry

Dopamine analogues are reported to have remarkable biological activities. Levodopa and carbidopa are the active ingredients of drugs used for the treatment of Parkinson and Alzheimer diseases. Methyldopa is another molecule belonging to the same class of compounds and is used as hypertensive drug. Concurrent ingestion of the metal ions can cause marked changes in the bioavailability of these drug molecules. In the present study, interaction of dopamine analogues with the bioessential metals like iron, copper, and aluminum is investigated. These bioessential metals have a significant role in the normal functioning of the brain and nerves. The work is aimed to establish a convenient, simple, and fast method through which the complexation of dopamine analogues with different bioactive metals can be explored. For this purpose, cyclic voltammetric probe is used and electrochemical parameters of electroactive drug in the presence and absence of metal ion are served as an analytical tool. It was found that the drug molecule undergoes coupled chemical reaction with the metal ions, and this interaction is pH dependent. Electrochemical behavior of the drug molecule was found to be changed in the presence of the metal ion.