Methyl 3,3-difluoro-2-trimethylsilyloxyacrylate: preparation and mukaiyama-type aldol condensation as a novel route to β, β-difluoro-α-keto ester derivatives
2002
Abstract Mukaiyama-type aldol condensation of arylaldehyde acetals occurs smoothly with methyl 3,3-difluoro-2-trimethylsilyloxyacrylate (derived from ethyl 3,3-difluoro-2-benzoylacrylate) when catalyzed by a Lewis acid, allowing preparation of 4-alkyloxy-3,3-difluoro-2-keto esters in high yields.
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