New indazoles substitutes, their preparation and their use in therapeutic

The invention relates to compounds of formula (1) wherein:. E denotes a graupement (i) of the formula -NT-CO-O- or -NT-CX-NT'- wherein X denotes = 0 or = S and T and T ', which may be identical or different, are independently selected from H or an alkyl group or (ii) forming a 5- or 6 chainonsqui is attached in position 5 or 6 to the indazole ring by -nt- or by the N1 nitrogen atom ;. R1represente one or more substituent (s) selected independently of one another when there are several, which can be a halogen atom, alkyl, alkenyl, alkynyl, haloalkyl, haloalkoxy, aryl, heteroaryl , heterocycloalkyl, cycloalkyl, CN, NRR ', OR, nOZ, COOR, CONRR', NRCOR ';. R2represente hydrogen, alkyl, alkenyl or alkynyl;. R3represente one or more substituent (s) selected independently of one another when there are several and can be a halogen atom, alkyl, alkenyl, alkynyl, haloalkoxy, aryl, heteroaryl, cycloalkyl , heterocycloalkyl, CN, NRR ', CF3, OR, NO2, COOR, CONRR', NRCOR ';. R4designe a hydrogen or halogen atom, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycloalkyl, -NR-CO-R ', COOR, NRR', CHO, CONR (OR '). R and R ', which may be identical or different, denote, independently of one another: hydrogen, alkyl, aryl, heterocycloalkyl, cycloalkyl or heteroaryl;. n1represente an integer ranging from 0 to 5 and n3un integer from 0 to 3.